Association and interaction of PPARα, δ, and γ gene polymorphisms with low-density lipoprotein-cholesterol in a Chinese Han population.

ABSTRACT:

Aims

Elevated low-density lipoprotein-cholesterol (LDL-C) is regarded as one of major risks of cardiovascular diseases and atherosclerotic events. It has been previously reported that peroxisome proliferator-activated receptors (PPARs) play an important role in the regulation of lipid metabolism. In this study, we aimed to investigate the influence of PPARα/δ/γ gene polymorphisms on LDL-C level. Eight hundred twenty unrelated participants were recruited. Ten single-nucleotide polymorphisms (SNPs) were genotyped to analyze the gene-gene interactions among these polymorphisms using the generalized multifactor dimensionality reduction (GMDR) method.

Results

The results of single-locus analyses indicated that the genotypes with minor allele variants at the rs1800206, rs9794, rs1

SUBMITTER: Fan W 

PROVIDER: S-EPMC4507121 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature