Reconstruction of the temporal signaling network in Salmonella-infected human cells.

ABSTRACT: Salmonella enterica is a bacterial pathogen that usually infects its host through food sources. Translocation of the pathogen proteins into the host cells leads to changes in the signaling mechanism either by activating or inhibiting the host proteins. Given that the bacterial infection modifies the response network of the host, a more coherent view of the underlying biological processes and the signaling networks can be obtained by using a network modeling approach based on the reverse engineering principles. In this work, we have used a published temporal phosphoproteomic dataset of Salmonella-infected human cells and reconstructed the temporal signaling network of the human host by integrating the interactome and the phosphoproteomic dataset. We have combined two well-established networ

SUBMITTER: Budak G 

PROVIDER: S-EPMC4507143 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature