The Dark Side of the Force - Constraints and Complications of Cell Therapies for Stroke.

ABSTRACT: Cell therapies are increasingly recognized as a promising option to augment the limited therapeutic arsenal available to fight ischemic stroke. During the last two decades, cumulating preclinical evidence has indicated a substantial efficacy for most cell treatment paradigms and first clinical trials are currently underway to assess safety and feasibility in patients. However, the strong and still unmet demand for novel stroke treatment options and exciting findings reported from experimental studies may have drawn our attention away from potential side effects related to cell therapies and the ways by which they are commonly applied. This review summarizes common and less frequent adverse events that have been discovered in preclinical and clinical investigations assessing cell therapies

SUBMITTER: Boltze J 

PROVIDER: S-EPMC4507146 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature