Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV4 channels.

ABSTRACT:

Background and purpose

Eugenol, a vanilloid molecule found in some dietary plants, relaxes vasculature in part via an endothelium-dependent process; however, the mechanisms involved are unclear. Here, we investigated the endothelial cell-mediated mechanism by which eugenol modulates rat mesenteric artery contractility and systemic BP.

Experimental approach

The isometric tension of rat mesenteric arteries (size 200-300 μm) was measured using wire myography; non-selective cation currents (ICat ) were recorded in endothelial cells using patch clamp electrophysiology. Mean arterial pressure (MAP) and heart rate (HR) were determined in anaesthetized rats.

Key results

Eugenol relaxed endothelium-intact arteries in a concentration-dependent manner and this effect was attenua

SUBMITTER: Peixoto-Neves D 

PROVIDER: S-EPMC4507154 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature