Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations.

ABSTRACT: While South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture. We present the results of the EPIGEN Brazil Initiative, the most comprehensive up-to-date genomic analysis of any Latin-American population. A population-based genome-wide analysis of 6,487 individuals was performed in the context of worldwide genomic diversity to elucidate how ancestry, kinship, and inbreeding interact in three populations with different histories from the Northeast (African ancestry: 50%), Southeast, and South (both with European ancestry >70%) of Brazil. We showed that ancestry-positive assortative mating permeated Brazilian history. We traced European ancestry in the Southeast/South to a wider European/Middle Eas

SUBMITTER: Kehdy FS 

PROVIDER: S-EPMC4507185 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature