Dynamical malaria models reveal how immunity buffers effect of climate variability.

ABSTRACT: Assessing the influence of climate on the incidence of Plasmodium falciparum malaria worldwide and how it might impact local malaria dynamics is complex and extrapolation to other settings or future times is controversial. This is especially true in the light of the particularities of the short- and long-term immune responses to infection. In sites of epidemic malaria transmission, it is widely accepted that climate plays an important role in driving malaria outbreaks. However, little is known about the role of climate in endemic settings where clinical immunity develops early in life. To disentangle these differences among high- and low-transmission settings we applied a dynamical model to two unique adjacent cohorts of mesoendemic seasonal and holoendemic perennial malaria transmission i

SUBMITTER: Laneri K 

PROVIDER: S-EPMC4507245 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature