Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89.

ABSTRACT: The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.

SUBMITTER: Pandya DN 

PROVIDER: S-EPMC4507282 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature