An SOS Regulon under Control of a Noncanonical LexA-Binding Motif in the Betaproteobacteria.

ABSTRACT:

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The SOS response is a transcriptional regulatory network governed by the LexA repressor that activates in response to DNA damage. In the Betaproteobacteria, LexA is known to target a palindromic sequence with the consensus sequence CTGT-N8-ACAG. We report the characterization of a LexA regulon in the iron-oxidizing betaproteobacterium Sideroxydans lithotrophicus. In silico and in vitro analyses show that LexA targets six genes by recognizing a binding motif with the consensus sequence GAACGaaCGTTC, which is strongly reminiscent of the Bacillus subtilis LexA-binding motif. We confirm that the closely related Gallionella capsiferriformans shares the same LexA-binding motif, and in silico analyses indicate that this motif is also conserved in the Nitrosomonadales and the Me

SUBMITTER: Sanchez-Alberola N 

PROVIDER: S-EPMC4507345 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature