Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells.

ABSTRACT: Immunosuppressed patients are frequently afflicted with severe mycoses caused by opportunistic fungal pathogens. Besides being a commensal, colonizing predominantly skin and mucosal surfaces, Candida albicans is the most common human fungal pathogen. Mast cells are present in tissues prone to fungal colonization being expectedly among the first immune cells to get into contact with C. albicans. However, mast cell-fungus interaction remains a neglected area of study. Here we show that human mast cells mounted specific responses towards C. albicans. Collectively, mast cell responses included the launch of initial, intermediate and late phase components determined by the secretion of granular proteins and cytokines. Initially mast cells reduced fungal viability and occasionally internalized y

SUBMITTER: Lopes JP 

PROVIDER: S-EPMC4507480 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature