Nocturnal Sleep Dynamics Identify Narcolepsy Type 1.

ABSTRACT:

Study objectives

To evaluate the reliability of nocturnal sleep dynamics in the differential diagnosis of central disorders of hypersomnolence.

Design

Cross-sectional.

Setting

Sleep laboratory.

Patients

One hundred seventy-five patients with hypocretin-deficient narcolepsy type 1 (NT1, n = 79), narcolepsy type 2 (NT2, n = 22), idiopathic hypersomnia (IH, n = 22), and "subjective" hypersomnolence (sHS, n = 52).

Interventions

None.

Methods

Polysomnographic (PSG) work-up included 48 h of continuous PSG recording. From nocturnal PSG conventional sleep macrostructure, occurrence of sleep onset rapid eye movement period (SOREMP), sleep stages distribution, and sleep stage transitions were calculated. Patient groups were compared, and receiver operating

SUBMITTER: Pizza F 

PROVIDER: S-EPMC4507733 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature