Clinical significance of laryngopharyngeal reflux in patients with chronic obstructive pulmonary disease.

ABSTRACT:

Background

Although chronic obstructive pulmonary disease (COPD) is closely associated with gastroesophageal reflux disease (GERD), the clinical significance of laryngopharyngeal reflux (LPR) is not fully understood in COPD.

Methods

Prospective cohorts were established among 118 patients with COPD from March 2013 to July 2014. Thirty-two age-matched and sex-matched normal controls, who had routine health check-ups during the study period, were included. Laryngopharyngeal reflux finding scores (RFS) and reflux symptom index (RSI) for LPR were subjected to association analysis with severity and acute exacerbation of COPD during the 1-year follow-up.

Results

The mean age of patients enrolled in the study was 69.2±8.8 years, with 93.2% being male. Positive RFS (>7) and RS

SUBMITTER: Jung YH 

PROVIDER: S-EPMC4507795 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature