Insulin, Central Dopamine D2 Receptors, and Monetary Reward Discounting in Obesity.

ABSTRACT: Animal research finds that insulin regulates dopamine signaling and reward behavior, but similar research in humans is lacking. We investigated whether individual differences in body mass index, percent body fat, pancreatic β-cell function, and dopamine D2 receptor binding were related to reward discounting in obese and non-obese adult men and women. Obese (n = 27; body mass index>30) and non-obese (n = 20; body mass index<30) adults were assessed for percent body fat with dual-energy X-ray absorptiometry and for β-cell function using disposition index. Choice of larger, but delayed or less certain, monetary rewards relative to immediate, certain smaller monetary rewards was measured using delayed and probabilistic reward discounting tasks. Positron emission tomography using a non-displace

SUBMITTER: Eisenstein SA 

PROVIDER: S-EPMC4507849 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature