Shared and distinct intrinsic functional network centrality in autism and attention-deficit/hyperactivity disorder.

ABSTRACT:

Background

Individuals with autism spectrum disorders (ASD) often exhibit symptoms of attention-deficit/hyperactivity disorder (ADHD). Across both disorders, observations of distributed functional abnormalities suggest aberrant large-scale brain network connectivity. Yet, common and distinct network correlates of ASD and ADHD remain unidentified. Here, we aimed to examine patterns of dysconnection in school-age children with ASD and ADHD and typically developing children who completed a resting state functional magnetic resonance imaging scan.

Methods

We measured voxelwise network centrality, functional connectivity metrics indexing local (degree centrality [DC]) and global (eigenvector centrality) functional relationships across the entire brain connectome, in resting state

SUBMITTER: Di Martino A 

PROVIDER: S-EPMC4508007 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature