Differential Effects of Tissue-Specific Deletion of BOSS on Feeding Behaviors and Energy Metabolism.

ABSTRACT: Food intake and energy metabolism are tightly controlled to maintain stable energy homeostasis and healthy states. Thus, animals detect their stored energy levels, and based on this, they determine appropriate food intake and meal size. Drosophila melanogaster putative G protein-coupled receptor, Bride of sevenless (BOSS) is a highly evolutionarily conserved protein that responds to extracellular glucose levels in order to regulate energy homeostasis. To address how BOSS regulates energy homeostasis, we characterized a boss mutant by assessing its food intake and stored energy levels. Boss mutants exhibited increased food intake but decreased stored triacylglyceride levels. Using boss-GAL4 drivers, we found that boss is expressed in select tissues that are involved in nutrient sensing and

SUBMITTER: Kohyama-Koganeya A 

PROVIDER: S-EPMC4508045 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature