Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals.

ABSTRACT: Schizophrenia is a common psychiatric disorder with high heritability and complex genetic architecture. Genome-wide association studies (GWAS) have identified several significant loci associated with schizophrenia. However, the explained heritability is still low. Growing evidence has shown schizophrenia is attributable to multiple genes with moderate effects. In-depth mining and integration of GWAS data is urgently expected to uncover disease-related gene combination patterns. Network-based analysis is a promising strategy to better interpret GWAS to identify disease-related network modules. We performed a network-based analysis on three independent schizophrenia GWASs by using a refined analysis framework, which included a more accurate gene P-value calculation, dynamic network module se

SUBMITTER: Chang S 

PROVIDER: S-EPMC4508050 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature