Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain.

ABSTRACT: Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. The mechanism of action and the effects of electrical fields administered to the brain by means of an electrode remain to be elucidated. The effects of DBS have been investigated primarily by electrophysiological and neurochemical studies, which lack the ability to investigate DBS-related responses on a whole-brain scale. Visualization of whole-brain effects of DBS requires functional imaging techniques such as functional Magnetic Resonance Imaging (fMRI), which reflects changes in blood oxygen level dependent (BOLD) responses throughout the entire brain volume. In order to visualize BOLD responses induced by DBS, we have developed an MRI-compatible electrode and an acquisition protocol to per

SUBMITTER: Van Den Berge N 

PROVIDER: S-EPMC4508110 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature