Brain morphology links systemic inflammation to cognitive function in midlife adults.

ABSTRACT:

Background

Inflammation is linked to cognitive decline in midlife, but the neural basis for this link is unclear. One possibility is that inflammation associates with adverse changes in brain morphology, which accelerates cognitive aging and later dementia risk. Clear evidence is lacking, however, regarding whether inflammation relates to cognition in midlife via changes in brain morphology. Accordingly, the current study examines whether associations of inflammation with cognitive function are mediated by variation in cortical gray matter volume among midlife adults.

Methods

Plasma levels of interleukin (IL)-6 and C-reactive protein (CRP), relatively stable markers of peripheral systemic inflammation, were assessed in 408 community volunteers aged 30-54 years. All participa

SUBMITTER: Marsland AL 

PROVIDER: S-EPMC4508197 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature