The Impact of Inpatient Versus Outpatient Initiation on Early Warfarin Dosing.

ABSTRACT:

Background and objectives

Dosing algorithms for warfarin incorporate clinical and genetic factors but may not account for the numerous comorbidities affecting patients who start warfarin while hospitalized. We aimed to determine whether these algorithms perform differently when warfarin is initiated for inpatients compared with outpatients.

Patients and methods

We analyzed a prospective cohort of 1015 participants from the Clarification of Optimal Anticoagulation through Genetics (COAG) trial who were randomized to either pharmacogenetically or clinically guided warfarin dosing algorithms. Clinicians and participants were blinded to dose during the first 28 days. We compared groups, based on location at the time of the first warfarin dose request, in relation to the followin

SUBMITTER: Kasner SE 

PROVIDER: S-EPMC4508217 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature