The association of beta-2 adrenoceptor genotype with short-cervix mediated preterm birth: a case-control study.

ABSTRACT:

Objective

To determine whether β2 -adrenoceptor (β2 AR) genotype is associated with shortening of the cervix or with preterm birth (PTB) risk among women with a short cervix in the second trimester.

Design

A case-control ancillary study to a multicentre randomised controlled trial.

Setting

Fourteen participating centres of the Maternal-Fetal Medicine Units Network of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Population

Four hundred thirty-nine women, including 315 with short cervix and 124 with normal cervical length.

Methods

Nulliparous women with cervical length <30 mm upon a 16-22-week transvaginal sonogram and controls frequency-matched for race/ethnicity with cervical lengths ≥40 mm were studied. β2 AR geno

SUBMITTER: Miller R 

PROVIDER: S-EPMC4508241 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature