An Association Study on IL16 Gene Polymorphisms with the Risk of Sporadic Alzheimer's Disease.

ABSTRACT:

Background

Interleukin-16 (IL-16) is an important regulator of T cell activation and was reported to act as a chemoattractant agent. There are evidences that IL16 can control the neuroinflammatory processes in Alzheimer's Disease (AD). This study was performed to investigate the role or association of IL16 polymorphisms, rs11556218 and rs4778889 with the risk of late-onset Alzheimer's disease (LOAD) in Iranian population.

Methods

Totally, 148 AD patients and 137 nondemented and age-matched subjects were recruited in this study. Genotyping of rs11556218 T/G and rs4778889 T/C polymorphisms was performed by PCR-RFLP method using the NdeI and AhdI restriction enzymes, respectively.

Results

Statistical analysis of rs11556218 genotypes showed a protective effect against AD

SUBMITTER: Khoshbakht T 

PROVIDER: S-EPMC4508336 | biostudies-literature | 2015 Jul-Sep

REPOSITORIES: biostudies-literature