Synaptic Orb2A Bridges Memory Acquisition and Late Memory Consolidation in Drosophila.

ABSTRACT: To adapt to an ever-changing environment, animals consolidate some, but not all, learning experiences to long-term memory. In mammals, long-term memory consolidation often involves neural pathway reactivation hours after memory acquisition. It is not known whether this delayed-reactivation schema is common across the animal kingdom or how information is stored during the delay period. Here, we show that, during courtship suppression learning, Drosophila exhibits delayed long-term memory consolidation. We also show that the same class of dopaminergic neurons engaged earlier in memory acquisition is also both necessary and sufficient for delayed long-term memory consolidation. Furthermore, we present evidence that, during learning, the translational regulator Orb2A tags specific synapses of

SUBMITTER: Kruttner S 

PROVIDER: S-EPMC4508346 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature