Salvianolic acid A as a multifunctional agent ameliorates doxorubicin-induced nephropathy in rats.

ABSTRACT: Nephrotic syndrome (NS) is still a therapeutic challenge. To date there is no ideal treatment. Evidence suggest that multidrug therapy has more effect than monotherapy in amelioration of renal injury. Salvianolic acid A (SAA) is the major active component of Salviae Miltiorrhizae Bunge. Previous studies have demonstrated that SAA is a multi-target agent and has various pharmacological activities. The pleiotropic properties of SAA predict its potential in the treatment of NS. The study investigated the effect of SAA on doxorubicin-induced nephropathy. The kidney function related-biochemical changes, hemorheological parameters and oxidative stress status were determined, and histological examination using light and transmission electron microcopies and western blot analysis were also perform

SUBMITTER: Fan HY 

PROVIDER: S-EPMC4508635 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature