A panel of eight-miRNA signature as a potential biomarker for predicting survival in bladder cancer.

ABSTRACT:

Background

There is increasing evidence to suggest that miRNAs play an important role in predicting cancer survival. To identify a panel of miRNA signature that can divided tumor from normal bladder using miRNA expression levels, and to assess the prognostic value of this specific miRNA markers in bladder cancer (BCa).

Methods

A comprehensive meta-review of published miRNA expression profiles that compared BCa and adjacent normal tissues was performed to determine candidate miRNAs as prognostic biomarkers for BCa. Vote-counting strategy and Robust Rank Aggregation method were used to identify significant meta-signature miRNAs.

Results

We identified an eight-miRNA signature including three upregulated (miR-141, miR-200c, miR-21) and five downregulated (miR-145, miR-125

SUBMITTER: Zhou H 

PROVIDER: S-EPMC4508815 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature