Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes.

ABSTRACT:

Purpose

We compared across age-related macular degeneration (AMD) subtypes the effect of AMD risk variants, their predictive power, and heritability.

Methods

The prevalence of AMD was estimated among active non-Hispanic white Kaiser Permanente Northern California members who were at least 65 years of age as of June 2013. The genetic analysis included 5,170 overall AMD cases ascertained from electronic health records (EHR), including 1,239 choroidal neovascularization (CNV) cases and 1,060 nonexudative AMD cases without CNV, and 23,130 controls of non-Hispanic white ancestry from the Kaiser Permanente Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. Imputation was based on the 1000 Genomes Project reference panel.

Results

The narrow-sense heritabi

SUBMITTER: Shen L 

PROVIDER: S-EPMC4509058 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature