Associations between CTLA-4 +49 A/G (rs231775) polymorphism and cancer risk: a meta-analysis based on 52 case-control studies.

ABSTRACT:

Objectives

To date, a number of epidemiological studies have explored the association between CTLA-4 +49 A/G polymorphism and cancer risk with elusive results. To address this gap, we carried out a comprehensive meta-analysis.

Design and methods

Two reviewers independently searched the PubMed, EMBASE, CBM (Chinese BioMedical Disc) and China National Knowledge Infrastructure (CNKI) Databases for relevant studies up to December 20, 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) for CTLA-4 +49 A/G polymorphism and cancer risk were used to evaluate the strength of association.

Results

A total of 52 case-control studies were ultimately recruited. Our results showed the statistical evidence of an association between the CTLA-4 +49 A/G polymorphism and decreased

SUBMITTER: Wang L 

PROVIDER: S-EPMC4509167 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature