Early quantitative CT analysis of oleic acid induced acute respiratory distress syndrome in a canine model.

ABSTRACT:

Background

Although quantitative computed tomography (CT) has been used to analyze the lungs of patients with confirmed diagnoses of acute respiratory distress syndrome (ARDS), there are few reports to show the diagnosis during the early stage of ARDS. Using a canine model and quantitative CT, we aimed to develop an oleic acid (OA) induced ARDS regarding the early stage of ARDS that could improve in the early diagnosis of ARDS.

Methods

Fourteen healthy beagle dogs underwent CT. Their lung tissue was manually partitioned into four compartments, i.e., non-aerated, poorly aerated, normally aerated, and hyper-aerated lung compartments. The mean CT attenuation value Hounsfield unit (HU), tissue mass (g), residual volume (ml), and percentage of lung area were automatically determi

SUBMITTER: Chen H 

PROVIDER: S-EPMC4509184 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature