Screening feature genes of osteosarcoma with DNA microarray: a bioinformatic analysis.

ABSTRACT: To screen differentially expressed genes (DEGs) of Osteosarcoma (OS) by using the microarray expression profiles of tissues of normal person and patients with OS for early diagnosis and effective treatment of OS. We downloaded the gene expression profile of GES16088 from Gene Expression Omnibus database, including twenty samples from fourteen patients diagnosed with osteosarcoma and six normal samples as control groups. We identified the DEGs by Affy package in R language. Bioinformatic methods were used for further analysis of the screened DEGs. Firstly, cluster analysis was performed on the selected DEGs for comparison of the expression degree. After protein-protein interaction (PPI) network of differentially expressed genes was constructed by STRING, we analyzed gene functions with DAVI

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4509196 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature