Evaluating the microRNA-target gene regulatory network in renal cell carcinomas, identification for potential biomarkers and critical pathways.

ABSTRACT: Variant microRNA (miRNA) expression is a character of many cancer types. The combined analysis of miRNA and messenger RNA (mRNA) expression profiles is crucial to identifying links between deregulated miRNAs and oncogenic pathways. The aim of this study was to screen several novel genes associated with renal cell carcinoma (RCC), and analyze the gene functions and signal pathways which were critical to RCCs with DNA microarray. The gene expression profile of GSE6344 was downloaded from Gene Expression Omnibus database, including 10 RCC samples and 10 healthy controls. Compared with the control samples, differentially expressed genes (DEGs) of RCC was identified. The selected DEGs were further analyzed using bioinformatics methods. Gene ontology (GO) enrichment analysis was performed using

SUBMITTER: Li J 

PROVIDER: S-EPMC4509205 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature