Association of COX-2 -765G>C genetic polymorphism with coronary artery disease: a meta-analysis.

ABSTRACT:

Background

Previous studies suggested the single nucleotide polymorphism (SNP) of COX-2 -765G>C (rs20417) is associated with coronary artery disease (CAD), but the results were conflicting. In order to derive a more precise estimation of the associations, we performed a meta-analysis of the relationship between rs20417 and CAD in all published studies.

Method

Databases including PubMed, Web of Science, Wanfang, SinoMed and CNKI were systematically searched. Data were extracted using standardized methods. The association was assessed by odds ratio (OR) with 95% confidence intervals (CIs).The statistical tests were performed using Review Manager 5.3.3 and Stata 12.0 software.

Results

We identified a total of 14 studies involving a total of 18227 subjects. The pooled odd

SUBMITTER: Zhang MM 

PROVIDER: S-EPMC4509228 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature