Expression of CXCR4 and non-small cell lung cancer prognosis: a meta-analysis.

ABSTRACT:

Purpose

The prognostic value of aberrant C-X-C chemokine receptor type 4 (CXCR4) levels in NSCLC has been described in empirical studies. This meta-analysis evaluates the value of CXCR4 as a prognostic marker for NSCLC and determines the relationship between CXCR4 and clinicopathological features of NSCLC.

Methods

A comprehensive search of the English-language literature in PubMed, Embase, Google Scholar and Web of Science was performed. Articles containing sufficient published data to determine an estimate of the hazard ratio (HR) and a 95% confidence interval (95% CI) for over survival (OS) or disease-free survival (DFS) were selected. Of 417 potentially relevant studies, 10 eligible studies (1,334 NSCLC patients) met the inclusion criteria.

Results

Overall, high CX

SUBMITTER: Liu K 

PROVIDER: S-EPMC4509232 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature