Association analysis of GWAS and candidate gene loci in a Chinese population with coronary heart disease.

ABSTRACT:

Objective

Coronary heart disease (CHD), the most severe form of coronary artery disease (CAD), is a complex disease that involves a variety of genetic and environmental factors. Recently, multiple single nucleotide polymorphisms (SNPs) have been associated with CAD in Caucasians by genome-wide association (GWA) studies.However, the association of these SNPs with CHD in Asian populations has not yet been established. Here, we aim to investigate the genetic etiology of CHD in a Chinese population by genotyping SNPs previously been associated with CHD in other ethic origin in GWAS or candidate gene studies.

Methods

Five SNPs, rs17114036, rs9369640, rs515135, rs579459 and rs8055236, from 5 different loci were genotyped using a sequenom Mass array system in 545CHD patients and 10

SUBMITTER: Gao M 

PROVIDER: S-EPMC4509238 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature