Association between vitamin D receptor gene polymorphisms and breast cancer in a Chinese population.

ABSTRACT:

Objective

The present study aimed to explore the association between vitamin D receptor (VDR) genetic polymorphisms and breast cancer risk.

Methods

A total of 219 patients with breast cancer and 321 cases of females without breast cancer were enrolled for the present study. PCR-RFLP method was used to genotype 3 SNPs of the VDR gene (rs1544410, rs7975232 and rs731236). ELISA method was used to detect the amount of 1,25(OH)2D3 in the plasma. The results were analyzed using SPSS 17.0 software.

Results

We found rs7975232 was associated with breast cancer risk. Compared with GG genotype carriers, TT subjects had a lower risk of breast cancer (P = 0. 004, OR = 0.774, 95% CI: 0.212~0.955). However, there was no difference in 1,25(OH)2D3 levels among the different genotypes.

SUBMITTER: Guo B 

PROVIDER: S-EPMC4509310 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature