Association of CYP2J2 gene polymorphisms with ischemic stroke.

ABSTRACT: OBJECTIVE:The present study aims to investigate the relationship between CYP2J2 gene polymorphisms and ischemic stroke (IS) in a Chinese Han population. METHODS:We performed a case-control study including 300 stroke patients and 300 healthy control subjects to compare the distribution of genetic polymorphism G-50T in CYP2J2 gene. RESULTS:We found GT genotype of G-50T in CYP2J2 gene was associated with the risk for IS (13.7% vs. 7.7%, P = 0.037). After adjustment of confounders, the difference remains significant (OR = 1.890, 95% CI: 1.042-3.011). CONCLUSION:CYP2J2 gene polymorphism might increase the risk of stroke in Chinese population.

SUBMITTER: Li Q 

PROVIDER: S-EPMC4509331 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature