Fine-scale population structure of Malays in Peninsular Malaysia and Singapore and implications for association studies.

ABSTRACT: Fine scale population structure of Malays - the major population in Malaysia, has not been well studied. This may have important implications for both evolutionary and medical studies. Here, we investigated the population sub-structure of Malay involving 431 samples collected from all states from peninsular Malaysia and Singapore. We identified two major clusters of individuals corresponding to the north and south peninsular Malaysia. On an even finer scale, the genetic coordinates of the geographical Malay populations are in correlation with the latitudes (R(2) = 0.3925; P = 0.029). This finding is further supported by the pairwise FST of Malay sub-populations, of which the north and south regions showed the highest differentiation (FST [North-south] = 0.0011). The collective findings the

SUBMITTER: Hoh BP 

PROVIDER: S-EPMC4509480 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature