Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth.

ABSTRACT:

Objective

To identify possible mechanisms linking obesity in pregnancy to increased fetal adiposity and growth, a unique mouse model of maternal obesity associated with fetal overgrowth was developed, and the hypothesis that maternal obesity causes up-regulation of placental nutrient transporter expression and activity was tested.

Methods

C57BL/6J female mice were fed a control (C) or a high-fat/high-sugar (HF/HS) pelleted diet supplemented by ad libitum access to sucrose (20%) solution, mated, and studied at embryonic day 18.5.

Results

HF/HS diet increased maternal fat mass by 2.2-fold (P < 0.01) and resulted in glucose intolerance with normal fasting glucose. Maternal circulating insulin, leptin, and cholesterol were increased (P < 0.05) whereas total and high-molec

SUBMITTER: Rosario FJ 

PROVIDER: S-EPMC4509489 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature