Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.

ABSTRACT:

Background

Renin-angiotensin system activation is a feature of many cardiovascular conditions. Activity of myocardial reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH oxidase 2 or Nox2) is enhanced by angiotensin II (Ang II) and contributes to increased hypertrophy, fibrosis, and adverse remodeling. Recent studies found that Nox2-mediated reactive oxygen species production modulates physiological cardiomyocyte function.

Objectives

This study sought to investigate the effects of cardiomyocyte Nox2 on contractile function during increased Ang II activation.

Methods

We generated a cardiomyocyte-targeted Nox2-transgenic mouse model and studied the effects of in vivo and ex vivo Ang II stimulation, as well as chronic aortic banding.

Results

Chron

SUBMITTER: Zhang M 

PROVIDER: S-EPMC4509515 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature