The effect of oxidative stress polymorphisms on the association between long-term black carbon exposure and lung function among elderly men.

ABSTRACT:

Background

Black carbon (BC) is a pro-oxidant, traffic-related pollutant linked with lung function decline. We evaluated the influence of genetic variation in the oxidative stress pathway on the association between long-term BC exposure and lung function decline.

Methods

Lung function parameters (FVC and FEV1) were measured during one or more study visits between 1995 and 2011 (n=651 participants) among an elderly cohort: the Normative Aging Study. Residential BC exposure levels were estimated using a spatiotemporal land use regression model. We evaluated whether oxidative stress variants, combined into a genetic score, modify the association between 1-year and 5-year moving averages of BC exposure and lung function levels and rates of decline, using linear mixed models.

SUBMITTER: Mordukhovich I 

PROVIDER: S-EPMC4509588 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature