Impact of genetic similarity on imputation accuracy.

ABSTRACT:

Background

Genotype imputation is a common technique in genetic research. Genetic similarity between target population and reference dataset is crucial for high-quality results. Although several reference panels are available, it is often not clear which is the most optimal for a particular target dataset to be imputed. Maximizing genetic similarity between study sample and intended reference panels may be the straight forward method for selecting the genetically best-matched reference. However, the impact of genetic similarity on imputation accuracy has not yet been studied in detail.

Results

We performed a simulation study in 20 ethnic groups obtained from POPRES. High-quality SNPs were masked and re-imputed with MaCH, MaCH-minimac and IMPUTE2 using four different HapMap r

SUBMITTER: Roshyara NR 

PROVIDER: S-EPMC4509609 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature