Estimation of inbreeding using pedigree, 50k SNP chip genotypes and full sequence data in three cattle breeds.

ABSTRACT:

Background

Levels of inbreeding in cattle populations have increased in the past due to the use of a limited number of bulls for artificial insemination. High levels of inbreeding lead to reduced genetic diversity and inbreeding depression. Various estimators based on different sources, e.g., pedigree or genomic data, have been used to estimate inbreeding coefficients in cattle populations. However, the comparative advantage of using full sequence data to assess inbreeding is unknown. We used pedigree and genomic data at different densities from 50k to full sequence variants to compare how different methods performed for the estimation of inbreeding levels in three different cattle breeds.

Results

Five different estimates for inbreeding were calculated and compared in this s

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC4509611 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature