Validity of diagnostic codes and laboratory tests of liver dysfunction to identify acute liver failure events.

ABSTRACT:

Purpose

Identification of acute liver failure (ALF) is important for post-marketing surveillance of medications, but the validity of using ICD-9 diagnoses and laboratory data to identify these events within electronic health records is unknown. We examined positive predictive values (PPVs) of hospital ICD-9 diagnoses and laboratory tests of liver dysfunction for identifying ALF within a large, community-based integrated care organization.

Methods

We identified Kaiser Permanente Northern California health plan members (2004-2010) with a hospital diagnosis suggesting ALF (ICD-9 570, 572.2, 572.4, 572.8, 573.3, 573.8, or V42.7) plus an inpatient international normalized ratio ≥1.5 (off warfarin) and total bilirubin ≥5.0 mg/dL. Hospital records were reviewed by hepatologists to

SUBMITTER: Lo Re V 

PROVIDER: S-EPMC4509617 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature