Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.

ABSTRACT:

Background

Polychlorinated biphenyls (PCBs) are a group of man-made environmental pollutants which accumulate in humans with adverse health effects. To date, very little effort has been devoted to the study of the metabolism of PCBs on a genome-wide level.

Objectives

Here, we conducted a genome-wide association study (GWAS) to identify genomic regions involved in the metabolism of PCBs.

Methods

Plasma levels of 16 PCBs ascertained in a cohort of elderly individuals from Sweden (n=1016) were measured using gas chromatography-high resolution mass spectrophotometry (GC-HRMS). DNA samples were genotyped on the Infinium Omni Express bead microarray, and imputed up to reference panels from the 1000 Genomes Project. Association testing was performed in a linear regression fr

SUBMITTER: Ng E 

PROVIDER: S-EPMC4509719 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature