Fungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) involves dysregulation of mucosal immunity in response to environmental factors such as the gut microbiota. The bacterial microbiota is often altered in IBD, but the connection to disease is not fully clarified and gut fungi have recently been suggested to play a role as well. In this study, we compared microbes from all 3 domains of life-bacteria, archaea, and eukaryota-in pediatric patients with IBD and healthy controls.

Methods

A stool sample was collected from patients with IBD (n = 32) or healthy control subjects (n = 90), and bacterial, archaeal, and fungal communities were characterized by deep sequencing of rRNA gene segments specific to each domain.

Results

Patients with IBD (Crohn's disease or ulcerative colitis) h

SUBMITTER: Chehoud C 

PROVIDER: S-EPMC4509842 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature