Statins Provide Less Benefit in Populations with High Noncardiovascular Mortality Risk: Meta-Regression of Randomized Controlled Trials.

ABSTRACT:

Objectives

To examine whether the benefit of statins varied according to cardiovascular (CV) and non-CV mortality of the treated population.

Design

Meta-analysis and meta-regression of 16 randomized placebo-controlled trials.

Setting

Community and hospital.

Participants

Statin- (n = 59,671) and placebo-treated (n = 59,707) individuals with and without CV disease (mean age 55 to 75).

Measurements

Meta-regression was used to model relative risks (RRs) of major CV events (myocardial infarction and stroke) and total mortality for statins versus placebo as a function of CV and non-CV mortality risks of the study population.

Results

Every 1% increase in 5-year non-CV mortality risk of the study population was associated with a 3.7% (95% confidence inter

SUBMITTER: Kim CA 

PROVIDER: S-EPMC4509928 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature