Resting-state Functional Magnetic Resonance Imaging Correlates of Sevoflurane-induced Unconsciousness.

ABSTRACT:

Background

Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has been used to study the effects of anesthetic agents on correlated intrinsic neural activity. Previous studies have focused primarily on intravenous agents. The authors studied the effects of sevoflurane, an inhaled anesthetic.

Methods

Resting-state BOLD fMRI was acquired from 10 subjects before sedation and from 9 subjects rendered unresponsive by 1.2% sevoflurane. The fMRI data were analyzed taking particular care to minimize the impact of artifact generated by head motion.

Results

BOLD correlations were specifically weaker within the default mode network and ventral attention network during sevoflurane-induced unconsciousness, especially between anterior and posterior mid

SUBMITTER: Palanca BJ 

PROVIDER: S-EPMC4509973 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature