Cthrc1 controls adipose tissue formation, body composition, and physical activity.

ABSTRACT:

Objective

This study investigated the effects of loss of Cthrc1 on adipogenesis, body composition, metabolism, physical activity, and muscle physiology.

Methods

Complete metabolic and activity monitoring as well as grip strength measurements and muscle myography was performed in Cthrc1 null and wildtype mice.

Results

Compared to wildtypes, Cthrc1 null mice had similar body weights but significantly reduced energy expenditure, decreased lean mass, and increased fat mass, especially visceral fat. In vitro studies demonstrated that Cthrc1 inhibited adipocyte differentiation as well as PPAR and CREB reporter activity, while preadipocytes isolated from Cthrc1 null mice exhibited enhanced adipogenic differentiation. Voluntary physical activity in Cthrc1 null mice as assesse

SUBMITTER: Stohn JP 

PROVIDER: S-EPMC4509980 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature