The composition of cellular infiltrates in anti-HMG-CoA reductase-associated myopathy.

ABSTRACT:

Introduction

To characterize cellular infiltrates in muscle biopsies from patients with anti-3-hydroxy-3-methyl-gulatryl-CoA reductase (HMGCR)-associated myopathy.

Methods

Biopsies from 18 anti-HMGCR myopathy and 7 control dermatomyositis patients were analyzed.

Results

CD4+ and CD8+ T-cells were scattered within the endomysium in 50% of anti-HMGCR biopsies. All anti-HMGCR biopsies included increased endomysial and/or perivascular CD163+ M2 macrophages; CD11c+ M1 macrophages were present in 18.8%. CD123+ plasmacytoid dendritic (PD) cells were observed within the endomysium and perivascular spaces in 62.5% of anti-HMGCR biopsies. Membrane attack complex was deposited on endothelial cells in 50% and on the sarcolemma of nonnecrotic muscle fibers in 85.7% of anti-HMGCR c

SUBMITTER: Chung T 

PROVIDER: S-EPMC4510021 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature