Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models.

ABSTRACT: We simulate the pathophysiology of severe burn trauma and burn-induced sepsis, using rat models of experimental burn injury and cecal ligation and puncture (CLP) either individually (singe-hit model) or in combination (double-hit model). The experimental burn injury simulates a systemic but sterile pro-inflammatory response, while the CLP simulates the effect of polymicrobial sepsis. Given the liver׳s central role in mediating the host immune response and onset of hypermetabolism after burn injury, elucidating the alterations in hepatic gene expression in response to injury can lead to a better understanding of the regulation of the inflammatory response, whereas circulating cytokine protein expression, reflects key systemic inflammatory mediators. In this article, we present both the hepa

SUBMITTER: Rao R 

PROVIDER: S-EPMC4510136 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature