The Effect of Cigarette Smoking on Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

Studies suggest that smoking may be a risk factor for the development of microvascular complications such as diabetic peripheral neuropathy (DPN). The objective of this study was to assess the relationship between smoking and DPN in persons with type 1 or type 2 diabetes.

Research design and methods

A systematic review of the PubMed, Embase, and Cochrane clinical trials databases was conducted for the period from January 1966 to November 2014 for cohort, cross-sectional and case-control studies that assessed the relationship between smoking and DPN. Separate meta-analyses for prospective cohort studies and case-control or cross-sectional studies were performed using random effects models.

Results

Thirty-eight studies (10 prospective cohort and 28 cross-secti

SUBMITTER: Clair C 

PROVIDER: S-EPMC4510224 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature