The Kinetic Response of the Proteome in A549 Cells Exposed to ZnSO4 Stress.

ABSTRACT: Zinc, an essential trace element, is involved in many important physiological processes. Cell responses to zinc stress show time-dependent effects besides concentration-dependence and tissue-specificity. Herein, we investigated the time-dependent differential expression of the proteome in A549 cells after administered with ZnSO4 for both 9 and 24 h using 2DE. 123 differentially expressed protein spots were detected, most of which were up-regulated by Zn2+ treatment. Interestingly, 49 proteins exhibited significant differential expression repeatedly during these two treatment periods, and moreover showed a conserved change with different ratios and four time-dependent expression patterns. Pattern 1 (up-regulated with rapid initial induction and subsequent repression) and pattern 4 (down-reg

SUBMITTER: Zhao WJ 

PROVIDER: S-EPMC4510299 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature