Identification of Androgen Receptor Splice Variants in the Pten Deficient Murine Prostate Cancer Model.

ABSTRACT: Androgen receptor (AR) variants are associated with resistance to anti androgen therapy both in human prostate cancer cell lines and clinical samples. These observations support the hypothesis that AR isoform accumulation is a consequence of selective therapeutic pressure on the full length AR. The Pten deficient prostate cancer model proceeds with well-defined kinetics including progression to castration resistant prostate cancer (CRPC). While surgical castration and enzalutamide treatments yield an initial therapeutic response, Pten-/-epithelia continue to proliferate yielding locally invasive primary tumor pathology. That most epithelium remains AR positive, but ligand independent, suggests the presence of oncogenic AR variants. To address this hypothesis, we have used a panel of recent

SUBMITTER: Liang M 

PROVIDER: S-EPMC4510390 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature